Associated Diseases

This information is for research purposes only

Acquired Immunodeficiency Syndrome
● Alzheimer’s Disease
● Asthma
● Bipolar Disorder
● Brain Cancer
● Breast Cancer
● Chronic Fatigue Syndrome
Chronic Pain
● Colon Cancer
● Depression
● Diabetes
● Drug Abuse
● Endometriosis
● Fibromyalgia
● Heart Disease
● Hypertension
● Inflammatory Bowel Disease
● Kidney Cancer
● Liver Cancer
● Migraine
● Obesity
● Ovarian Cancer
● Pre-Eclampsia
● Pancreatic Cancer
● Parkinson’s Disease
● Prostate Cancer
● Rheumatoid Arthritis
● Schizophrenia
● Stomach Cancer
● Temporomandibular Joint Disorder

Scientific Studies, Organized by Date

  • 1979
    • Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
  • 1986
    • Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
    • Serotonin receptors influencing cell proliferation in the jejunal crypt epithelium and in colonic adenocarcinomas
  • 1988
    • 5-Hydroxytryptamine Receptor Subtypes
    • 5-Hydroxytryptamine receptor subtypes: molecular, biochemical and physiological characterization
  • 1989
    • 5-Hydroxytryptamine receptor “families”.
  • 1990
    • 5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries
  • 1991
    • New vistas on 5-HT receptors and migraine
  • 1992
    • 5-HT in nervous system disease and migraine
  •  1993
    • 5-Hydroxytryptamine Receptors
    • 5-Hydroxytryptamine receptor subtypes and the pharmacology of migraine
  • 1994
    • Receptors for 5-Hydroxytryptamine: Current perspectives on classification and nomenclature
    • 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates
    • International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)
    • Serotonin receptors and therapeutics
  • 1995
    • Characterization of the 5-hydroxytryptamine2A receptor-activated cascade in rat C6 glioma cells
    • Psychosis in advanced Parkinson’s disease: treatment with ondansetron, a 5-HT3 receptor antagonist
  • 1997
    • [Immunohistochemical locating and quantitative studies of 5-hydroxytryptamine and 5-hydroxytryptamine receptor in placental villi of patients with pregnancy induced hypertension].
    • Serotonin2A receptor gene polymorphism in mood disorders
  • 1998
    • 5-HT1A receptor hypersensitivity in migraine is suggested by the m-chlorophenylpiperazine test
  • 1999
    • A review of central 5-HT receptors and their function
  • 2000
    • 5-HT modifiers as a potential treatment of asthma
  •  2002
    • Molecular, pharmacological and functional diversity of 5-HT receptors
  • 2003
    • 5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer’s disease in the Basque Country
  • 2006
    • The role of serotonin (5-hydroxytryptamine1A and 1B) receptors in prostate cancer cell proliferation.
  •  2007
    • Changes on 5-HT2 receptor mRNAs in striatum and subthalamic nucleus in Parkinson’s disease model
  • 2008
    • 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder
    • Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT(1A) receptors
  •  2009
    • 5-Hydroxytryptamine Receptor Subtypes and Their Modulators with Therapeutic Potentials
  • 2010
    • Influence of 5-HT4 receptor activation on acetylcholine release in human large intestine with endometriosis
    • Peripheral 5-HT1A and 5-HT7 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats
  •  2011
    • Association of 5-hydroxytryptamine (serotonin) receptor 4 (5-HTR4) gene polymorphisms with asthma
    • C-122, a novel antagonist of serotonin receptor 5-HT2B, prevents monocrotaline-induced pulmonary arterial hypertension in rats
    • Genome-wide identification of chemosensitive single nucleotide polymorphism markers in gastric cancer
    • The serotonin-6 receptor as a novel therapeutic target
    • The 5-HT(2A) Receptor Antagonist M100907 Produces Antiparkinsonian Effects and Decreases Striatal Glutamate
  •  2012
    • Expression of serotonin receptors 5-HT1A, 5-HT1B, 5-HT2B and 5-HT4 in ovary and in ovarian tumours
    • Impact of 5-HT(3) receptor antagonists on peripheral and central diseases
    • Prostate cancer in elderly Croatian men: 5-HT genetic polymorphisms and the influence of androgen deprivation therapy on osteopenia–a pilot study
  • 2013
    • Expression and localization of serotonin receptors in human breast cancer
    • Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence
    • Relationship between genetic polymorphisms in the HTR1A gene and paranoid schizophrenia in a northern Han Chinese population
    • Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a
    • Serotonin transporter and serotonin receptors
  • 2014
    • Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells
  •  2015
    • Serotonin 5-HT2 receptor activation prevents allergic asthma in a mouse model
  • 2016
    • Activation of serotonin 5-HT(2C) receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in morphine-dependent mice
    • Novel multi-target-directed ligands for Alzheimer’s disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation
    • Serotonin 2A Receptor Inverse Agonist as a Treatment for Parkinson’s Disease Psychosis: A Systematic Review and Meta-analysis of Serotonin 2A Receptor Negative Modulators
  •  2017
    • Putative role of 5-HT2B receptors in migraine pathophysiology
    • Genetic and biochemical changes of the serotonergic system in migraine pathobiology